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https://dpe.ula24.top
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1. ?????????? ????????
2. ??????? ???酉�
3. ??????? ?????
4. ??????? ?? ????
5. ?????肉� ???? ??????? ???????
6. ????????? ???? ????? ?????? ??? ????
7. ??????? ??? ????
8. ??????? ??? ????
1. ?????????? ????????
???????(Mebendazole, MBZ)?? ?????????(Benzimidazole) ?瓦�?? ?????? ????? ?????? ?????(??????)??. ????, ????, ??? ?? ???? ?????嚥� ?罐? ??????. Vermox(??????, ??????)?? Ovex?? ????????? ??????? ?罐? ??????? ?? ?????. ????(???)?????? ?????? ?????? ???????.(????????? ?????????? ?????? ?????? ?????? ???? ??쨈?.)
2. ??????? ???酉�
1?? 100mg???? ???????? ????? 1?? 100~200mg?? ????? ???????. ?????????? ???? ???????. WHO ??????????? ????????(cystic echinococcosis, CE)?? 40-50mg/kg/day?? ???? 3~6???? ??????? ????????(alveolar echinococcosis, AE)???? 40-50mg/kg/day?? 2?? ??? ???????. 10?? ??? ?????? ??????? ???. ???? ???????? ??? ???? ??????? ?????.
3. ??????? ?????
?????? ??? ???? ??????? ???? ?????. ?????? ????? ???? ?酉�?? ???????? ????? ?? ??????? ???? ????? ?? ??? ??????? ?? ????? ?????? ???? ????? ??????? ???. ????? ???? ??????? ???????? ??????? ?琯??? ?????? ???理� ???? ???. ??? ????? ?????? ?? ????. 2?? ?????? ???? ??????? ???? ?????? ???????? ??쨈?.
4. ??????? ?? ????
??????????? ???????? 20% ?????? ???? ?? 2~4 ?챨? ?? ???? ?????? ???????. ?????? ???? ????? ??? ??????? ???????? ????????. 10mg/kg ?????? ??? ?????? ?????? 137.4ng/ml(0.47??M)????? ???? ???.
?첩?????? ????????? ?????? ???? ???? ????? ??????? ???? ?????? 1.5?? ???? ???灌?? ???? ???. ?첩???? ????? ?????? ????? ??????? ??????? ???? ???????? ?? ?????.(?첩?????? ??????? ????? ??????肉� ???? ???? ?克??? ??????? ???? ???? ????? ?????? ??????? ????? ??????? ???? ???????)
5. ?????肉� ???? ??????? ???????(?????? ?? ????????)
2002?? Mukhopadhyay?? ???????(?琯?)?? ???? ????????? ?????? ?????? ????????? ?酉� ?? ?챨? ?????????? ???? ?????? ???????? ?????? ??? ?????? ?? ???. 50% ???????(IC50)?? 0.16??M???. ?? ?????? G2/M????? ??????? ??????? ???? ?????? ??????? ????, ?????? ??? ???? ????????? ?????? ??????????? ??????? 1??M?? ?????????? ???????? ????? ??????? ????.?
?? ??, ????????? ????? ???? ????????? ??????, ?????, ??????, ?????? ?????? ??琯?? IC50?? 0.1???? 0.8??M?????.
???? ?????? ???? ?? ????? ???????? ?????? ?????? 3mm ???? ?????? ????, ??????? 1mg?? ????? ??????? ???? ???????? ?酉� ?????????? ??????? ???? ???? ????? ?????????. ??? ?? ???????? ?????? ??????????? ??琯?? ???. ???? ??????????? A549 ?????? ??????? ?? ????? ?????? ???? ???????? ???????? ??????? ??????? 21?? ???? ?? 300???? ?? ????? ??琯?????? ??????? 1mg?? ????? ?????? ???????? ?? ?????? ???? 80% ????? ?????? ??琯????. ?? ???????? ?????????? ??????????? ?????? ????. ???? ?? ?????????? ??????? ???? ??????? ????? ???.
?????????? ?????? 20g?? ???肄� 1?? 1mg?????? ??? 70kg?? ????????? 1?? 500mg?? ??????. ??? ?????? ????? 3/4??(??????? 0.751??)?? ???????? ????? ??????, ????????? ???肄�?? ??? ?? ?????? ???????? ???? ???? ????? ????? ?? 7???? ????? ???. ???肄�?? ???? 1mg/20g?? 50mg/kg, ??????? 7mg/kg?? ?????? 70kg??? 490mg?? ???? ???????? ???????? ?? ????? ???? 1?? 500mg ?????? ????? ?酉�??? ?? ?? ???.
????? ???? ??????(??? ??????) ?????? ??????? ?????? ?????? ??????? ?? 2000?????? ?????? ????????? ?????????? 10?????? ?????? ???? ??????? ?????? ???? ??? ??? ?????? ?????? ?????? ????????? ?? ?? 4 ?????? ??????????(benzimidazoles)?? ?????????. ?? 4???? ???????(mebendazole), ???????(albendazole), ?繹�????(fenbendazole), ?????????(oxybendazole)????? ?? ???? ????????? ???? ???????? ????? ?????? ?????? ?? ???.
????????? 2?????? ????? ?????? ??? ?????? ??????? ???? ?酉� ?????????? ?????? ??????? ????? ????째? IC50?? ???? 0.32??M?????. ????, ?????煐� ?????? ??????? ???? IC50?? 1.9??M?????.
??? ??? ?????? ?????? ???? ??(?? ???? ??)?? ????? ???????????? ????????? 1mg?? 2mg?? ????? ??????? ?????? ?????? ?????(??????? ??????)?? ???荑� ???? 1mg?? ???? 83%, 2mg?? 77%?? ???? ?????? ?????????. ????? 100mg/kg?? temozolomide(?????, ????? : ?????)?? ?????? 5?? ???? ?????? ??? ????? ???????. Temozolomide?? ??? ???????? ??? ??????? ??????? ??????? ?? ?????????? ?煐� ?????????? ??????? ???. ??? ??? ???????? ???? ????????? ??????????? ???酉�?? Temozolomide ?????? ??????? ??????, ???? ??????? ???? ????? ?징?? ????쨈?(Mol Cancer Res. 6 (8) : 1308-1315, 2008).
?? ?????? ?????? ??? ???????? 2???? ??????? ??????菅???? ????????? ????????, ???(M-14)?? ?????? p53?? ??????, ??? ???(SK-Mel-19)?? ???????? p53?? ???? ???????. ?????? ?? ?? ??????? ???? ??????????? ????? ???? ????????? ????? ???????? ?? ???? ?????? p53?? ???? ?????? ???????? ??????????? ??????? ???? ??????.
???? ?? ???? ????????? Bcl-2 ??????? ?貫????? ??????? ?????? ??????? ??커?????? ??????? ???. Bcl-2?? ????????? ????? ??????? ????????? ???肉� ???? ????????? ??????????? ???? ??????? ????? ??? ?????.
?????? ?????(glioblastoma multiforme)?? ???? ????????? ????? 2011?? ?荑�?? ???????. ??????????????? ????? ?? ????? ???????? ???? ?????? ?????? ?????? ???????? ?繹�????(Fenbendazole)?? ?????? ???? ????? ?????? ???????? ???? ?????? ??琯????. ?繹�?????? ?????? ??????? ?????????? ?瓦�?? ???????? ???????.
???? ?????? ???????, ???????????? ?? ?? ????????? ???? ??????? ??????????????? ?????? ??????? ?????? ????????. ?????? ???????? ???? ????? ?????? GL261?? ???? ????????? 50% ??????? ????(IC50)?? 0.24??M, ????? ????????????? ??????(060919)?? ???? IC50?? 0.1??M?????. ????????????? ?????? ?? ?????? ?????????? ????????? ?? ????(50mg/kg)?? ??????? ???????? ???????(63% ????) ?????? ???????(Neuro oncol 13 (9) : 974-982. 2011??).
??????? ??????? ???????? ????????? ????????? ??? ?????? ??琯????. ?? ?????????? 1600?????? ???? ?????? 2?????? ?????? ??????(HCT116?? RKO)?? ??????? ?? ??? ????? ??????? 64?????? ?????? ????? ?????. ?? ??? ?????????(benzimidazoles)?? ?? ???????(albendazole), ???????(mebendazole), ?????????(oxybendazole) ?繹�????(fenbendazole)?? ??????? ??? ????????? ????????? ??????????? ?????????. ?? ?? ?????? ????? ?????? ??? ???????? ???琯? ?? ???? ??? ??????? ??? ?????? ?? ??? ?????????? ???.
??????, ??????, ??????, ??? ???????? ?????? ?????? ????? ????쨈?.
?????? ??????? ??????? 80%?? ??????? ???? ????????? ??????????? ????쨈?. 5?????? ?????? ??????(HCT 116, RKO, HT29, HT-8 and SW626)?? ????? ???????? IC50?? ???? ?????? ?????????? 5??M ???????, ?????????? ??????? ???? ?????? ??琯??? ????.
????? ???? ?????? ??????(SKBr-3)?? ????? ?????????? ???????????? ???? ?????? ??????? ????? ????쨈?. ????????? ???? ???? ??????????? ??????, 0.5??M ???????? ?????? ?????? ???????? 63.1% ????????.(J Clin Exp oncol 02 (02) DOI : 10.4172 / 2324-9110.1000109)
?? ?????? ?????? ????? ?????????? ????????? ????????? ?????? ?? ??? ???????? ?????? ?????? ??????? ???????? ?????????? ???????.
6. ????????? ???? ????? ?????? ??? ????
????????? ????????? ?????? ????? ???? ????????? ?????? ???????????? ???? ??????? ???? ?????? ??? ?????? ???? ???.
?? ????? ?館????????? ???? ?????? ????? 2011?? ?????????.
?館????????? ?? ??? ???????? ?????? ?? ???? ???荑�?? ??????? ??????? ???? ????? ???. ?? ????????? ???? ????? ??? ??????? ????? ???????? ??? ?????????. ??? ??????? ???? ??? ???, ???? Pubmed ???? ??????? ?館???????? ????????? ??????????? ???????? ????? ?????????? ????. ????? ?????? ??????? ???? ?????? ?????? ?????? ???????? ?????(???? ????) ???????? ????????? ??????? ?????.
????????? 1? 100mg?? 1?? 2? ??????? ?????? ????? ??? ?????? ??????? ?????? ???????. ?????? ??????? ?????? ????? ??????? 19???? ???? ???? ????(???? 커???? ???)?? ?????????.
??????? ???? ??琯??? ??? ???? ??(QOL)?? ? ??째 ???? ?? ??????? ?????????. ????? ??????? ?????? ??????? 24???? ?커? ?????? ?????? ??琯?? ?????罐?????(everolimus)?? ?????????, ????? ??????? ????.(Endocr Prac 17 (3) e59-62 DOI : 10.4158 / EP10390.CR)
?? ??? ???? ???????? ????? ????????? ?????? ????? 2013?? ?????????.
74?? ?????? ????? ???? ????????? ???? ??????? ???????? + ????潁�????? + bevacizumab?? ????????? ????? ????, ???????? + ???????????? ?????? ?????. ?? ?? ?????? ????? ??琯??? ??? ????? ????????? ?????????. ??????? ??? ?????? 6?? ???? ?? CT??玲�?? ???? ?????? ?????? ???? ???????? ?? ????? ?????? ????? ?????? ???????. ????? ?? ?????? ??????(AST?? ALT?? ????) ????????? ??????? ?????? ??????? ?? ?????? ?????? ???? ???????? ??? ???????. CT??玲�?? ?????? ????? ??琯????. ??? ?????? 3?????? ???? ?? ?? ????? ??琯?? ???? ??? ???? ?????? ????? ??????? ?????? ????????? ????? ????? ?? ????? ?????? ??? ?????????. ???? 5???? ??????? ??? ??? 1????? ?觀? ????? ?????????.(Acta oncol 57 (3) 427-8, 2013 ??)
7. ??????? ??? ????
?? ????? ????????? ????? ??????? 2???? ????????? ???? ???? ?????. ???? ?????? ??????????. ????? ???????????極??? ????????? ?????? ??????罐???? ??? ???? ???? ????? ?????????? ???? ???????? ?? ??1?? ????? ????. 1?? 1500mg(500mg?? ??????????? 1?? 3? ????) ??????罐?????? ?????? ?????? ???酉� ???? ?? ????? ???? ???????.
?? ??? ??? ?????? ???? ???? ????????(Cohen Children 's Medical Centre)???? ???? ???? ??????? ???????? ????????, ???????, ??????罐?????? ??? ??????? ??1??, ??2?? ???????????. ???肉� ???? ??? ????? ?????????? ???罐? ??????? ?????. 100mg?? 1?? 2?, 70?? ????? ??? ?????? ??? ??????? ???.
8. ??????? ??? ????
???????? ????????? ??????????? ??罐?(tubulin)?? ?????? ??????? ???? ?極??? ????? ?????? ??? ???????? ?????? ??????? ????? ??????? ???. ?????? ???????灌? ????????(?????; ???)?? ???????? ???? ???. ????????(paclitaxel)?? ??罐??? ?????? ?????????館? ??????(microtubule)?? ???????? ??????? ?極??? ???????.
???????? ???? ???? ??罐??? ?????? ??????? ????? ?? ?? ??-??罐??? ??????? ?????? ?????????館? ???????? ???????. ????, ????????? ??罐??? ??????? ???????? ?????? ???????. ????????? ??罐??? ????? ???? ?????恝? ???????.
*???????? ??-??罐??? ??-??罐??? ?????? ????????(????? ?????)?? ???????? ???????, ??罐? ?????????? ???????? ?????? ???? ?????? ???????? ???, ????? 13?? ???? ?????? ????(???? 25nm)?? ???? ???? ?????????.
???? ?極??? ??????? ?? ???? ?????? DNA?? ??????? ?????? DNA?? ???????? ????? ?極? ?? ?????? ?????? ?????? ???. ????????? ??罐??? ??????? ???????? ?????? ??????? ???? ?極??? M?? ???????? ???? ?????? ???????.
???酉�?? ??????? ????????? ???, ????, ?琯???, ???? ????, ?????? ????? ????? ?? ???. ????? ??? ?????? ??????(?????蘊� ??? ????????)???? ?? ?? ??? ?????? ?????? ?????? ????. ??罐??? ????? ???? ?????恝??? ?????? ???????? ???????? ??? ?????? ????? ???.
?????? ???? ????? ????????? ??????? ??????? ???. ?? ???? ?????? p53 ?????? ?????? ???????? ?????? ???????? ???? ??????, p53?? ???????? ??????? ????? ????????? ?????? ????? ??????? ?????? ?????????.
???? ??? ???? ??肉� ???????? ?????? ???.
?????? ???????? ?????蘊� ??? ???????? ???酉�???? ????款???? ??????? ???? ??????? ????? ???(*???酉�?? ???? ???? ??????? ????? ????? ????款??? ????????(Metronomic Chemotherapy)???? ???). ????????? ???? ?? ????????? ??????.
????????? ?????????? ??罐??? ????? ???? ?????恝? ??????? ?????? ?????? ??????? ??????? ???? ?????? ?戮�????? ???. ?戮�????? ?????? ????? ???????????. ?戮�????? ???? ??? ???? ??? ???? ?????? ????? ??????? ???.
??? ?????? ?????? ?????? ???????? ?????????? ??????? Bcl-2 ??????? ?貫????? ???????? ?????????? ??????? Bax?? ??????? ?????????? ??????? ????? ??????? ???. Bcl-2 Bax?? ???? ??????? ?????????? ???????. Bcl-2 ??????? ?貫????? Bax?? ??????? ???, Bax?? ??? Bax?? ????????? ??????? ??? ?????????? ???????? ??커???????.(Mol Cancer Res. 6 (8) : 1308-1315, 2008)
*Bcl-2?? Bax?? ??????? Bax?? ?????? ???????? ????? ??? ????????? ???? ???????? ?????????館? ?????????? ???????. ????????? Bcl-2 ??????? ?貫????? ?????????. ?? ???? ??????? ?? Bax?? ????????? ??? ?????? ????(?????)?? ??? ?????? ??????? ???????????? ??????? C?? ?????? ????? ??????? ???????? ??????? ????? ??????? ????????(Caspases)?? ??????? ?????????? ???????.
????????? ??????? ????款??? ?? ????????(?? ??????????????? ???酉�???? ???酉� ????), ???????(????? ???????), ????????(????? ???????), ?????????(????? ?????????) ?? ??????? ???? ??????? ?????? ????? ?????? ?????? ??????? ?????? ????? ?????? ??????? ??????? ???.
*????????? VEGF ??????? ????? ????? ??????? ???? ????? ???????
???? ??????? ???????? ?????(Vascular Endothelial Growth Factor Receptor, VEGFR)?? ???? ??????? ???? ????(VEGF)?? ???????? ??? ??????? ??館???????? ???????? ???? ????????? ????? ???? ????, ???? ?????? ???? ?? ???????. ??????? ???? ?????? ????? ?????? ??????? ?????? ?첩??? ???? VEGF?? ?????? ???????. VEGF?? ???? ????????? VEGFR?? ?????? ???? ????? ???????.?
??????, VEGF ??????? ?????? ??????? ????? ???? ????? ??????? ????? ??? ???? ?????? ?????? ??????? ????? ??????? ???. VEGFR???? ?? ???? ????????? ????, ???? ????? ???? ??? ??????? VEGFR-2?? ??館?????? ????? ??????? ????? ????????? ???? ??????? ??? .
*???? ????????? ???? ??????? ???????? ?????-2(VEGFR-2)?? ???? ??????? ????????(VEGF)?? ??????? VEGFR-2?? ?????? ??????? ???? ?? ??館?????? ?????恝? ??????? ??館? ????? ????貫???? ???, ???? ?? ???????? ??????? ???? ????????? ???? ?? ???? ?????? ??????? ???? ????? ???????.
?? ?????? ??????? ???? VEGF?? ?克????. ???? ?????? ??????? ?????? ?????? ????? ????? ???????. ????????? VEGFR-2?? ?????? ??????? ???? ????? ???????.
?????? ????(Drug Repositioning)?? ???荑�??, ??????? ???????? ?? ????? ??? ???? ?? ?????? ???? ?????? ?????? ??????? ???? ???? ?????? ???? ?????? ?????? ???????? ????? ??????? ???????? ????? ?????????. ????? in silico(????? ?????)?????? ??? ???????? ????????? VEGFR-2?? ??????? ?? ????? ??????? ????? ???? ??????? ???.
????? ?????? ???? ????????? ?????? ?????? ????????? VEGFR-2?? ??????? ?? ????? ??????? ???? ????????? ????? ???? ?? ???? ????? ??????? ???? ??琯?? ???(J Cancer Res Clin oncol 139 : 2133-2140, 2013).
???? ????????? ???? ????? ?????? ?????? ??????? ????? ?????????. ?????? ???? ???? ??????.
Mebendazole reduces vascular smooth muscle cell proliferation and neointimal formation following vascular injury in mice (????????? ???肄�?? ???? ????? ???? ??? ???? ????? ?????? ????? ??? ???? ?????? ???????) PLoS one 2014 Feb 27; 9 (2 ) : e90146. doi : 10.1371 / journal.pone.0090146. eCollection 2014.
????????? ???????? ???????? ?????? ?????????館? ?? ????? ??????. ???? ????? ?????? ???????? ???? ???? ?????? ??? ????????? ??????? ?????? ???????? ???? ?????? ?????? ???????? ???肄�?? ?????? ????? ???????? ???? ????? ?????? ???커? ???? ????????? ????? ???????.
???肄� ???? ????? ?????? ????? ???????? ????????? ????? ?????? ????? ????? ??????? ?? ????? ???? ?? ???????? ?????? ????? ?????? ???. ??? ???????? ???? ????? ?????? ???? ????? ??????? ???? ????????? ?????? ???肄�?? ?????? ??(?????)???? ?????????? ??????? ????? ???? ???? ????? ???????. ???? ??? ?? ???? ????? ?????? ????? ??? ?? ??? ?????? ?????? ??????? ???? ?????? ?????? ?? ???? ?????????.
?????? ?????? ????? ?????? ????? ??????? ???????? ????? ?????? ??????? ??? ?????? ?????? ?????. ?? ?????? ???????? ???? ????????? ??????? ?貫??? ???? ?????????? ???? ???????. ?? ???????? ???? ?????????? ??????? ????? ???? ???????? ????????? ????????? ???? ??????? ????? ??? ?????? ?????? ???????? ?????. ?????? ????????? ?????? ?? ???? ????? ?????? ???커? ??????? ???? ????? ??? ?????????? ??????? ?????? ???????.
????????? ???? ??????? ??? ???? ???? ????? ?????? ????? ???????? ??????? ???? ??? ??????肉� ???? ?????? ????? ?????? ?? ?????? ?????? ???.
??? ??? ?????觀??? ????????? ?? ??????極? ??? ?????? ???? ???? ???쨈?? ???? ?? ???? ?????.
???? ????
Repurposing Drugs in oncology (ReDO) -mebendazole as an anti-cancer agent(?????極??? ?????? ???? ?? ???? : ??????關??? ???????),
Ecancermedicalscience 2014; 8 : 443.Published online Jul 10, 2014 . doi : 10.3332 / ecancer.2014.443
*????????? ?????? ?? ??? ????
-????????? ??玲� ??? 1kg?? 5~10mg?? ???????? ???????. ??????? 1???? 100mg???. ??????? 1?? 2??(200mg)???? ??????? ?????? ?????? 1?? 3-6?????? ?첩????? ???.
-???커? ???????. ???? ???? ?????? ???? ????? ???????.
-?첩?????? 1?? 400~800mg ???????. ?첩?????? ?? ????? ?????? ????? ????????? ????????? ????? ??????? ???? ?????? ????? ????? ???.
