???????: ?????? ???? ?????
?????????,?????? ????,?þ???? ????,???????þ????????,?????? ????,??????? ???,???н? ????ð?,?????????,???н????????,????????????,?????????,?þ??????????.??????? ???????????? ???? ?????? ???? ?????? ??????
???? ???????? ??????? ???? ????? 100% ???????, ?????? ????????ø? ???? ???н????? ???????. ????? ??????? ?????????? ??? ?? ???????! ???? ???????? ????? ??????????. ?????? ????? ???? ????? ???? ??????. ?????? ??????? ???????? ???? ????????. ???? ??????? ????? ????? ?????????.
??????? - ????? ??????
????? ???? ???. ????????????? ????? ???? ???? ??? ?? ??? ????? ??????. ??? ????????? ??? ?????? ?????? ?? ?? ???? ??????, ??? ?????? ???????? ?? ????? ???????? ???????.
????? ??????(Viagra) ????? ??? ????????????. ???? ???????? ??????? ????? 2013?? ??????? ????????????. ??? ???? ??? ??????? ?? ???? ?????? ???? ?????? ?? ????????. ???? ??? ???? ?? ?????????? ???????? ??? ??? ???? ??????? ???? ?????簡 ??? ???? ?????? ??????????.
???????? ??? ??????? ???? ????? ???? ?????? ????? ????????, ??? ???? ?????? ??? ?????? ?? ???? ?????? ???????? ??? ????? ??????? ????????. ????? ?????? ?????? ?? ?????????? ???????? ?????? ??????, ?귣?? ?????? ?? ?? ?????? ????? ???? ???? ???????? ??????? ???? ??????? ??????.
?????? ???? ?? ???
???????? ??????? ????? ????????, ????????? ??? ???? ?????? ???? ?????? ?? ??????. ???? ?????????? ???????? ?????? ??? ???? ??????? ????? ??????? ???? ???? ????. ????? ????? ??? ???¿? ???? ??????? ?????? ?Ŀ? ??????? ???????.
??? ?????????? ???????? ?¶??ο????? ?????? ?? ??????, ????? ???쿡?? ????????? ??????? ???????. ?¶??ο??? ?????? ?????? ????? ?? ??? ?¶??? ??? ???????? ???? ????? ??? ???? ???????.
???????? ?????? ??? ???? ??? ???? ?????????, ?? ?????????? ????? ??????. ???? ????? ?????????? ?????? ????? ?? ??? ?????? ???? ???????? ????????. ????? ???????? ????? ???? ???????? ??????? ???? ???? ?????? ?????? ?????? ??????.
????????????
???????? ????????? 25mg, 50mg, 100mg?? ?? ???? ?뷮???? ????????. ????? ????? ???¿? ???信 ???? ??簡 ????? ?뷮?? ???? ??? ?? ??????.
???? ??????? ???????? ?????? ???? 50mg?? ?뷮?? ???????, ??信 ???? ?뷮?? ?????? ?? ??????. ????? ????? ???? ?????? ?뷮?? ??????? ??????? ????.
???????? ?????? ?? ?? 30?п??? 1?ð? ???? ???????, ????? ??? ??????? ????? ????? ?? ??????. ?????? ??????? ???? ?????? ???? ??? ????? ???? ???????. ???? ??翡 ?? ???? ??????? ???, ????? ????? ???? ?뷮?? ???????? ???? ?????? ??????? ????.
?þ????
?þ????(Tadalafil)?? ?????? ????(ED) ?? ??????????? ??? ??????? ??????. ?? ???? ???? ?????? 1991?????? ????? ???????, ???? ???????? ?????? ICOS Corporation?? ?? ???? ???? ???? ????????? ??????????.Icos Corporation?? 2007?? ???? ???? ??? ?????(Eli Lilly and Company)???? ???????????.
ICOS Corporation?? ????????? ?????? ??? ??????? ??? ?? ?쿬?? PDE5(?λ????? 5) ???????? ?????? ????? ?????????. ????? PDE5 ???????? ???? ????? ??????? ???????? ????????? ??й????? ????????????? ?????λ꿰(cGMP)?? ?????? ??????????.
???? ICOS Corporation?? ????????? ?? ????? ?????? ???? ??? ??????? ??????????. ????? PDE5 ???????? ?????? ????? ??? ?????? ?????? ?????? ??????? ???????? ??????? ?? ???? ???? ?????????. ?? ?????, ??? ???????? ????? ?þ?????? ???????? ???????? PDE5 ?????????? ?????????, ??? ???? ??? ?????? ??????????.
??? ?????? ?þ?????? ??????? ??????? ????????? ???????????, ?????? ???? ????? ?????? ?????? ?????? ?? ?????? ??ε???????. ???? 2003?? ??? ??????(FDA)???κ??? ?????? ??? ?þ?????? ?????? ???? ??????μ? ?θ? ??????? ???? ????????.
?????? ???? ?????? ????, ?þ?????? ??????????? ????? ????? ???? ???? ????????????. ??? ???? ?? ?о???? ???? ?????? ??? ?????? ??ξ?????, ??? ?α? ??? ???? ????????.
???????
???????(Levitra)?? ??? ????(ED) ??? ???? ????????, ?? ???????? ?????????(Vardenafil)?? ??????? ??????. ?? ???? ?η??? ???? ????? ???? ???? ?????? ??????? ?????? ????????? ?????? ????.
????????? ??????????????(GlaxoSmithKline)?? ?????(Bayer)?? ???????? ?????? ???????. ??????? ?????????????? ?????? ??????????, ?? ?????? ?????? ??????? ???? ?????? ???????? ???????? ??? ?????? ??????????.
????????? 2003?? ??? ??????(FDA)?? ?????? ???????, ???? ????? ???????? ??????????. ??? ?????? ???? ???????? ?????? ????? ???????, ????????? ????? ???????? ??? ????? ??????? ??????.
????????? ????? ??濡 ???? ????????? ???, ???? ???? ??? ???????? ??????? ????. ???????? ???¿? ???????? ?????? ??????? ??????? ?????? ?뷮?? ???? ?????? ????????? ????. ????, ??????? ????? ?? ??????? ???? ?? ????? ???????.
????? ????? ???? ????? ???? ?? ??????? ??? ???????? ??????, ???? ?????? ???? ???? ???????. ????????? ???? ??? ???? ??????? ??????? ??????? ????? ????? ???? ?????? ??????? ????.
????????? ???? ?????? ????
???? ????:
???????(Levitra)?? ????? ??濡 ???? ????????? ???, ???? ???? ??? ???????? ??????? ????. ????? ????????? ??????? ???? ??ħ????:
1. ??????? ??ħ?? ????????: ????????? ??????? ???? ????? ????? ?????? ????. ??簡 ??????? ?뷮?? ???? ?????? ????? ?????? ????.
2. ????? ?뷮 ????: ??簡 ??????? ?뷮?? ?????????. ????????? ????? ?뷮???? ???????, ?????? ???¿? ???? ?????? ?뷮?? ????????.
3. ????? ??? ????: ????? ??? ????????? ??????? ????? ??????? ??????. ????? ???? ????? ???? ??? ????? ???? ???????. ?????? ????? ???? ??????? ????? ???? ?? ??????.
4. ?? ???? ?ð?: ????? ????? ???? ????????? ??????? ???? ?? ???? ?ð??? ????????. ????????? ???? ??? 25~60?? ???? ??????? ???? ????????.
5. ????? ???? ???: ????????? ??????? ???? ????? ???? ?? ??????? ??? ???????? ??????. ???? ?????? ???? ???? ???????.
6. ??? ?????? ?????? ????: ??? ?????? ?????? ??????? ???????, ????????? ??????? ???? ??翡?? ???? ???? ???? ???? ?? ?? ???????? ????????.
7. ????? ????: ??????? ???? ?? ??????? ????? ?? ???????, ???? ??????? ??翡?? ????? ????.
????????? ??? ??? ???? ??????? ???뿡 ???? ????? ?????? ??????? ?????? ???? ???? ???? ???????. ????, ??????? ??ħ?? ?????? ?????? ????.
????:
????????? ?????? ?????? ???????:
1. ??????? ??? ???? ???: ????????? ?????? ??? ?????? ?????? ?? ?????????. ??? ?????? ??????????? ?????? ??????? ?????? ???????? ??? ?????? ??????????.
2. ???? ???: ????????? ???? ??? 25~60?? ???? ??????? ?????? ????? ????? ?? ??????.
3. ???? ???? ???: ??? ?????? ????????? ?????? ?? ??? ?????? ??? 4~5?ð? ???? ????? ?? ???? ??????????.
4. ????? ??? ???? ????: ????????? ????? ??? ??????? ????? ???????? ??????. ?????? ????? ???? ?ð??? ??????? ????? ?????? ?? ??????.
5. ????? ?뷮 ????: ????????? ????? ?뷮???? ??????? ????? ???¿? ?°? ?????? ?뷮?? ?????? ?? ??????.
6. ???????? ??? ????: ????????? ??????(FDA) ???? ???????? ?????? ???????, ???????? ????? ???? ????? ?????? ??? ?????? ????????.
????? ???????? ????? ????? ????? ???? ?????? ?????? ?? ????????? ???? ??? ?????? ??????? ?????? ????.
????? ???????????? ????
????? ???? ???????????(orally disintegrating film, ODF)?? ?????? ?? ???? ?÷????? ?? ???? ?쿩?? ?????? ?? ??? ??? ?????? ??????.
???н? Vinix
???н??? ??????? ???? Clpharm ???? ??????? ???.???????? ??????????? ???? ?о?? ???? ???? ?????? ODF ?????? ?????? ?????, 2003?? ????????????
???н? ?? 1?? 1? ?????? ?? 1?ð? ???? ?????뷮 50~100mg ?????? ????????. ??? ??????? ???? ?????? ???? ???? ??? ?? ???? ???? ?쿩?? ?? ???? ??????? ????. ???н? ????ð??? 4?ð? ???????? ??????????? ????뿡 ????? ??????δ°??? ?????.
????? Sentrip
??????? ??????????????? ?????? ??? ???? ?쿩??? ????????. ????????????????20mg ?? ????? ??????? ?????? ???????? ?????? ???? ?????? ??????????ν? ??? ????????? ????????.
??????? ??????? ??????? ??????, ?????????δ? ?????? 30?? ?????? ?????? ?? ??????, ??? ???? ???? ?????? 1?? 1?, ?????뷮?? 10mg ?????. ???????? ???? ?????? ???? ???Ŀ? ??? ?? ???? ???? ?쿩?? ?????? ??????? ??? ??????? ??? ?????? ?? ??????.
?????????????????????
SK?????? '?????????? 50mg'?? ????ε?, ????? '??????' ?? ???????? ???? ???? ?δ?.?¡?? ???? '??????'?? ?????? ??????? ?????? ?????? ????????? ????? ???????? ????(ODF)???? ?????? ??.
ODF?? ???뼺 ???????? ?????? ?????????.
?? ????????(???? ??????????? ????)?? ???? ???? ???? 16.7% ???? ?????????. ?? ????? ???? ???????.
??????? ????? ???? ??????! ????? ??????, ????? ???????
?????? ???? ?????: ??????? ??????? ????
- ???????? ????????
- ?????? ???? ?? ????????
- ???????? ????? ?????
- ?????? ???? ????
???????? ?????? ??????? ??? ??????? ????, ???? ????? ???? ?? ?????? ???????? ??? ???????. 2025?? ????, ???? ???????? ?? ???? ???? ?????? ?????? ??????.
???????? ?????? ???? ?? ???? ????? ?????? ??????? ????. ????, ????? ????? ??? ???? ?????????. ??? ?????? ?????? ???????, ?????? ??? ???¿? ?´? ?????? ?뷮?? ??????? ?? ?????? ????.
???????? ????? ????????? 30?п??? 1?ð? ????? ???????, ??? 4?ð????? ????? ?? ??????. ????? ???? ???? ?????????? ??????? ???? ?? ??????. ??????? ????????δ? ????, ???? ???, ??? ??? ???? ??????, ????? ???쿡?? ???? ????? ??????? ????.
?????? ?????? ????? ??????? ????? ?? ??? ????? ?¶??? ?÷????? ?????? ???? ???????. ??????? ???θ? ???? ??????? ???? ????? ?????? ????? ?? ??????? ??????? ????.
?????: ??????, ???????, ?????? ????