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?첸?????? ??????? ??? ??????? ????????, ???? ???????? ?????? ??????? ?????? ???? ????????. ?첸???? ????????? ???????? ???????? ????????? ????? ??? ?????? ?첸???? ??????? ??????, ?쨋??? ?????? ?첸???? ??????? ?????? ??????. ??? ???玲�???? ?????? ?첸???? ????? ???? ?? ???? ?????? ????? ????? ??????????.
1.???????? ????????? ????? ??? ?????? ?첸???? ??????? ????
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2.?쨋??? ?????? ??????? ????
?쨋??? ?????? ?첸???? ????????? ?????? ??????. ?? ?????? ?????? ???? ?????? ?? ???? ?????? ??????. ?????, ?쨋??恝??? ??????? ???荑�?? ????? ????? ?? ??? ????????? ??????? ???, ?????? ?????? ????????? ???? ??????? ????. ????, ????? ?????? ????? ??? ?????????? ??????? ??? ?????? ?????? ?? ??????. ??????, ?첸???? ??????????? ????? ?????? ???? ???????? ?????? ???? ???? ???????, ???? ???? ?????? ?? ?? ??? ????????. ?쨋??恝??? ??????? ???荑�?? ????? ????? ?? ??? ???????? ??????? ???, ????????? ???????. ???????? ??????? ?????? ???????? ???챨? ????? ???? ????? ?? ??????, ????? ?????? ????? ???? ???? ?????? ????????? ?? ?? ??????.
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???????? ????? ??? ?????? ?첸???? ??????? ??????, ???? ???????? ??????? ?????? ??? ??, ??????? ??? ?????? ?첸???? ?????? ?? ?? ??????. ?? ?????? ???????? ?????? ????? ????? ??? ????? ???? ?????? ???酉�?? ?? ?? ???? ?????? ??????. ????, ????? ?酉�?? ???????? ?????? ??????? ????, ??????? ?????? ?? ??????. ??????, ?? ???????? ???? ?????? ????恝??? ?????? ???李� ??????. ?? ????? ?????? ???? ??????? ???? ???????? ?????? ??? ????? ??? ?????? ????????? ?????? ?????? ?쨋??? ?첸???? ???? ???커? ???? ?????????? ???? ?????? ???????. ????, ???????? ?????? ??? ??????? ???? ????, ????恝? ?? ??????.???????, ???????? ????? ??? ???? ????? ?????? ??? ??, ????? ?酉�?? ???????? ?? ?? ??? ????? ?? ????? ???? ?????? ?????? ?? ??? ???? ?????? ????????. ????, ???????? ?????? ?????? ?????? ????????? ??????? ??? ??? ?????? ????? ?????? ?? ??? ???? ?????? ?????? ????????.??????, ?????? ?첸???? ???? ?? ??????, ???????? ???????? ??????? ?????? ???? ????? ??? ???? ???? ???????, ????? ???? ?????? ?? ?? ??? ????????. ?????? ????恝??? ???? ?? ??????, ????? ?????? ??????? ??? ?????? ????? ??????.
?쨋??恝??? ?첸???? ??????? ????
?쨋??恝??? ?첸???? ????????? ??????, ?????? ???? ????? ?刮? ?????? ???????, ??????? ????? ????? ???? ?? ??? ???????? ?????? ??????. ??? ???????? ?쨋??恝??? ?첸???? ????????? ?????? ???? ????? ???????????.
??? ???????? ?????? ????? ????? ????? ???? ?? ?????? ?첸???? ???? ?? ??? ??????? ???????? ?? ???? ?첸???? ???? ????? ???觀? ?쨋????? ???? ?첸???? ????? ??? ??????. ??? ?쨋??恝??? ?첸???? ??????? ???? ?????? ???? ????? ?刮? ?????? ???????, ??????? ????? ???? ?? ??? ??????? ????????. ????, ?쨋??恝??? ?첸???? ????????? ???荑�?? ???? ?? ??? ???????? ??????? ??? ???? ?????? ???????? ???? ??????? ?????? ?? ??????. ?????, ?쨋??恝??? ?첸???? ????????? ???荑�?? ??????? ?? ???? ??????. ??? ?????????? ????????? ?????? ??? ?첸?????? ?????? ???李� ???????, ????? ????? ?? ??? ???????? ?첸???? ?????? ??? ????. ????, ????????? ??????? ??? ??? ?????? ????? ?? ??? ????? ????? ????? ???????, ?쨋??恝??? ?첸???? ?????? ?????? ?? ??? ????? ??챨? ???????째? ????躍�???. ?????, ???? ?? ??? ???????? ???????, ?쨋??恝??? ?????? ?첸???? ???? ??? ???? ?????? ???? ????? ?刮? ????? ?????? ?????? ?? ?? ??????. ???? ????, ?????? ???? ???? ?? ??? ???????? ?첸???? ?????? ???, ??? ???? ?????? ???????? ???? ??????? ?????? ?? ??????.
??????, ?쨋??恝??? ?첸???? ??? ??????? ???? ?????? ??????? ????? ???逾� ???? ??????? ????? ?????? ????? ?????? ??????.
?첸???? ?????? ?????? ????!
?????????? ?첸???? ????? ??? ?????? ?????? ?筠??? 9??????? ???? ?????? ??????? ?????? ?????? ??? ?첸???? ?????? ?????? ??????????. ????? ???? ???? ?????? ??????? ??????? ?????????? ?????? ?쨋??? ??????. ?????????? ??????? ???? ????? ?????? ??????? ????? ?????? ?刮? ???????, ????? ????? ????????. ????, ???????? ????????? ???? ????? ?????? ??耳�???? ???????, ?????? ???? ????? ?????? ?????? ????????. ?????????? ?첸?????? ???????, ?????? ???? ????? ?????? ???????, ?????? ???? ???????? ????? ??????? ?????? ??? ???? ?????? ???? ???????. ????, ???????? ?첸???? ?????? ???? ?????????? ??????? ??????? ????? ?????? ?????? ???????, ??????? ??????? ??????? ?????? ?? ?? ????? ???? ??????. ?????, ?쨋??恝??? ?첸???? ??? ???? ??? ???荑�?? ??????? ?? ???? ??????. ??? ?????????? ????????? ?????? ??? ?첸?????? ?????? ???李� ???????, ????? ??? ?????? ????????? ???????? ?첸???? ????????? ????. ????, ????????? ??????? ??? ??? ?????? ????? ?? ??? ????? ?????? ???????, ?쨋??恝??? ???????? ?? ????? ????? ????? ???? ?????? ??????? ???? ?????????? ???? ????躍�???. ??????????, ???????? ?????? ???? ????? ?????? ??耳�???? ??????? ???? ?? ??? ???????? ?첸???? ????? ??????? ??????, ????????? ?????? ?????? ?? ??? ????? ????????. ??????, ????? ?????? ??? ?커? ??????? ???, ????????? ??? ????? ?????? ?????? ?? ??????? ????.
?첸?????? ????
??????(Tadalafil)
???????? PDE5?? ??????? ????????? ??????? ???? ?? ??? ????????? PDE5?? ????????? ?????? ????? ??????? ?????? ?????????. ????? ??????? ????? ICOS?? ??????????(Galaxo Wellcome, ?????? GSK)?? ??????? PDE5?? ??????? ?????? ???????? ?????. ????? ?????? ?????? ???? ????? ???? PDE5?? ????????? ???-???????-3-????????(ethyl-carboline-3-carboxylate)?? ????????? ????, PDE5?? ???? ???? ????? ?????? ???? ?????? ????????? ???. ????? PDE5?? ???? IC50?? 5nM?? ????? ?????? ????????, ?? ?????? IC351???? ??????? ???????. ?? ?????? ???????????? ???????? ???? ?????? ????? PDE5 ??????????? ???? ??? ??閨????? ???? ?????????.????? ?????????? ????????? ?????? ?????? ??????觀??? ??????? ??????? ????? ??? ????, IC351?? ???? ???? ????????? ??????館? ?????? ??????? ?????, 1995?????? ??? 1???? ????????. ????? ????? ??????? ??? ?????? ?????? ?????? ???? ???????? ???? ??????? ??????? ????? ?????????, ICOS?? ?????? ?????? ?????? 1996?? ??????? ?????. ICOS?? ???? ???恝? ??????? ????(Eli Lilly)?? ?????? ???? ICOS(Lilly ICOS)???? ????????? ?????? IC351?? ??????? ??????館??? ??? ?????? ??????? ?????. 2002?? ????? ??? ?????????????(AmericanUrological Association)???? ???? ??????(Tadalafil)????? ???龜????? ????? ?? ???? ????????? ????????. ????? ???? ???? ???????? ???? ?? 36?챨? ???커??? ????? ???????? ????????, ?? ?????? ???????? ????????? ??????? 17.5?챨????館? ????????? 4?챨??? ????? 4?? ??? ???? ?????????. 2003?? FDA?? ???????? ???? ?????????, ???????? ???첸????(Cialis)?????? ????????? ????? ?????????. ????? ?????? ?첸???? ??? ???? ?????????????? 2016?? ???? 43?? ??? ????? ?????? ???? ????? ???? ???恝? ???? ?????? ?????? ?????. ???? ???? ?????? ??? ????肉�?? ????? ???? ????? ???? ????????? ?????? ????? ??? ????? ????????? ?????? ??? ?????? ????? ?????? ????????? ??????? ??? ???? ???????? ?? ??????? ???. ???? ????? ???????? ???? ???????? ?????? ?????? ?????? ??????? ???? ?????????? ?????? ??? ???????? ??????? ???.??????館? ???? ????? ?????? ??????觀??? ??????? ???? ?????? ???? ???? ?????? ??????? ??????? ????? ?????? ????? ?? ????? ???? ???玲� ???? ???? ??????? ???. ???? ?????? ?管??? ???????? ?????? ??? ??????????? ?????? ???玲� ???? ???? ????? ????????? ???.
?첸?????? ???
?첸?????? 1998?? ??????? ??????? ??? ????? ????, ?? ?????????? ???? ???????? ?慣? ?????????. ??? ???玲�???? ?첸?????? ???? ???? ?????????????? ????.
?첸?????? ??? ???????? ??, ??????? ??????關??? ????? ??? ?? ????? ?????? ?????? ???? ?? ?????????? ? ????? ???????. ?????? ?????? ?????? ?????????? ???????? ???? ?? ?????????? ?慣? ??? ??? ?? ????? ???????, ???? ?????????? ? ?????? ??????. ?첸?????? ??? ????? ??, ????? ?????? ?? ?????? ? ?慣? ?????????. ???, ??? ????? ????? ?????? ?첩??? ????? ??????? ??????? ???????????. ????? ?慣??? ?酉� ?????? ???? ?????? ???????? ???? ???? ????????????. ????, ?첸???? ?????? ???? ???? ?????? ?????????? ????? ??? ????????. ????? ???????? ???? ?첸???? ?? ?????? ???? ???????? ?????? ????? ???? ???????? ??????? ????????????. ????, ?? ???????? ?慣??? ????? TV ?????? ???? ????????? ??????? ?????? ???? ????? ??觀??? ????????.
?첸?????? ???
?첸????(Tadalafil)?? ?????? ???? ?? ?????? ?筠??? ??? ??????? ??? ?????? ?????? ???? ??????? ?? ?? ???????. ???????? ??????????, ?첸?????? PDE-5 ???????? ?鈞????, ?????? ??????? ???????? ???????? ?????????. ?????, ?? ???? ????? ?????, ???? ???? ???? ???? ????? ??????. ?첸?????? 2003?? FDA?? ???琯? ???????? ??????? ???? ????? ??????. ?첸?????? ??? ?????? ?????????, ???????? ?????????? ?????? ??????? ??? ???????? ?????????. ?????, ?첸?????? ?????????? ?? ????? ?????? ??????. ???????? ???? ?? 4?챨? ???? ????? ?????????, ?첸???? ????? ??? 36?챨????? ????? ???????. ??? ?첸?????? ?????? ??????? ?챨? ?????? ??????? ?????? ????? ?????? ?? ??? ?????? ????????? ? ???????? ?館????.?????, ?첸?????? ??????? ???????? ????????. ???? ??????? ??????? ????, ????????, ?????? ???? ??????. ????, ?첸?????? ?????? ????? ????? ???????, ???逵??????? ??????? ????, ?????? ???? ??????? ?????? ????? ?? ??????. ????, ?첸?????? ??? ??????? ???????? ??? ???? ??????? ??????? ?? ??????. ?????? ???? ?? ?첸???? ?????? ???????? ???? ?? ???? ???? ?????? ?????? ???? ??????? ????????. ?????, ?? ???? ???? ???????? ???????, ???????? ????? ???????? ???? ???? ?????? ?? ??????.
???????? ????
???????? ??????? ??????關? ?????????? ???? ???????? ??????? ????, ???? ??????? ?????????. ?????, ?????? ?첸???? ???? ?? ??? ?????? ?????? ?? ??? ??? ???? ??????. ??? ???玲�???? ???????? ?????? ??????筠? ????????? ????.
1, ?첸????(Tadalafil)?? ???????? ?????????? ??????? ?????????. ???????? ?????, ?첸?????? ????? ??? ??????? ????? ???? ?? ??? ?????? ??????. ????, ?첸?????? ????? ??? 36?챨????? ???????, ?? ???? ?챨? ???? ?????? ????? ???? ?? ??????.
2, ???????(Vardenafil)?? ???????? ?첸?????? ?????? ????? ??? ??????? ?????????. ?????????? ???? ????? ????? ??????, ?? ???? ????? ????? ???荑�?? ????????? ?????? ?? ??????.
3, ???????(Caverject)?? ????????? ??? ????? ???쨌? ??????? ??????? ?????????. ????????? ???, ????????? ???? ???? ?????? ???????? ????????. ????? ???쨌? ??????? ??? ????? ??? ?????? ???????????, ???????? ?????? ????? ?????? ????? ?? ???? ?? ??????? ????. ?????, ?????? ?????? ?????? ???? ??????? ??????? ??? ???? ???? ?? ???????. ???????? ?????????? ??????? ???????, ??????? ????? ???? ??? ????? ???? ??? ???????? ??????? ????????. ??????, ???????? ????????? ??? ???? ???????? ??????? ??????? ?? ????? ???? ?????? ?????? ???? ???????.
?첸???? ?????? ??????쨔???
1.???????? ??????? ????
??????? ???? ????????, ?첸?????? ???????? ????????. ??? ???? ??? ??????? ???關?, ?????? ??? ?? 30??~1?챨? ???? ??????? ????? ????????. ??????, ?첸?????? ??? ??????? ????? ???? ???? ????? ????? ?? ??????? ????? ???? ?? ??????? ????.
2.??????? ????
?첸???? ???? ?? ??????? ??????? ?????? ?첸???? ????? ?????? ????????? ??? ???荑� ????????. ?첸?????? ??????? ?????? ?첸???? ????????? ??????? ??????. ????????? ???? ?????, ?첸?????? ?????? ???????? ?????? ???????? ??? ???????.
3.?????? ????
?첸?????? ????? ???쨌琯? ????????. ?????? ?????? ???? ???? ?????? ??????? ????????. ?첸?????? ????????館? ?????? ???????? ?????? ???????? ??? ???????. ?????, ???? ?????? ?????? ?????, ??????? ????? ?? ??????? ????? ???? ?? ??????? ????.
4.???????? ??????? ????
?첸?????? ???????? ??? ??????? ?????? ??????. ????? ??? ??????? ?????? ?????? ?첸?????? ????? ??? ????????. ??????, ?첸?????? ????? ??? ????????? ??? ????, ????? ???? ?? ??????? ????.
5.???? ???? ??????? ????
?첸?????? ???? ???? ???쨌琯? ????????. ???? ???? ???쨈? ?????????? ??????? ????? ?????, ???? ??? ???????? ??? ??? ?????? ?? ??????. ???? ???? ???쨌? ??????? ????
?첸?????? ???? ??? ??????? ????? ?? ???? ?????? ???? ???????? ??????? ??????? ??????, ?????? ??? ?????? ??????? ????????.
6.???????? ??????
?첸???? ???? ?? ???????? ??? ?筠??? ???????? ????????? ?????? ???? ?? ????? ???????? ??????????. ?? ?????? ??????? ???? ??????? ???? ???恝? ???? ??????? ????????, ????????? ?????? ????? ?? ??????. ?????, ???????? ??? ?????? ??? ???罐?, ?????? ???? ?????? ??????? ??????, ?첸?????? ??? ??????? ??????? ?耳� ??????? ??? ??????.
???? ???? ?첸?????? ????? ???? ?????? ??????. ?????, ?첸?????? ????????? ???荑�?? ????? ??????? ?????? ???? ?????? ???????, ???? ?????? ????? ?????? ????. ????, ?첸?????? ??????? ????? ???? ???? ????? ??????? ????.
?첸???? ????? ???? ?????? ???? ??????
- ?첸?????? ??????????
- ????? ???? ?첸?????? ??????? ????
- ??? ???????? ?????? ??鴉�
- ?쨋??恝??? ???? ???? ?? ???????
- ?????? ?????? ??????? ???? ??
?첸?????? ???????? ?????? ????? ?????? ???? ??????? ?? ?? ?????, ???? ???????? ??????? ???????? ????? ??????. ?????? ??? ???? ???? ?????? ????????? ???????? ????? ??? ????? ????? ???????.
???????? '????? ???? ?첸???? ????'????? ??????? ?????? ????? ???????? ??????. ????? ????? ???????? ???觀? ????????? ?????? ??????? ???? ??????? ???????. ???, ????? ???? ???? ????? ??????? ??? ???????? ??????? ?????? ????? ?? ??????. ??????, ?? ?????琯? ????? ???? ?첸?????? ????????? ???? ????? ??????? ????????? ????.
?????? ????? ??? ???? ???? ???? ??? ?? ???? ??? ???????? ??????? ??????. ??????? ?????? ??? ???쨍? ??????? ?????? ??????? ???????, ????? ???? ?첸???? ????? ?????? ????? ??? ????? ?????? ?? ??????. ????, ??????? ????? ???? ????? ??????? ??? ?????? ???? ?? ???? ?????? ?? ??????, ??? ?????? ???? ????? ?????? ??? ?? ??????.
?쨋??恝??? ?????? ?????? ???? ??? ??????? ????. ?????????? ???????? ??????? ??????? ?????? ??? ?????? ?????? ???? ?????? ??????. ??? ??????? ????? ????? ???? ???? ??? ???? ????? ??? ?????? ????? ???? ??????. ??????, ??? ????? ?? ??? ????? ???????, ?????? ?? ???? ??????? ?????? ??????? ???? ???????.
??????????, ????? ??????? ??????? ??????? ??????? ??, ???? ???? ???, ?????? ???? ?? ?????? ??? ???? ?????? ???????. ????? ??? ???? ????? ????????? ???????? ????????? ?? ?????? ?? ?? ??????. ???? ??? ?????? ??????? ????????, ???????? ?????? ???? ???? ???? ???? ????????.
?????: ?첸????, ?????? ????, ?????, ??? ??????, ?쨋??? ??? ????, ????? ??? ????
